DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment.

@article{Perrotti2005DeltaFosBAI,
  title={DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment.},
  author={Linda I. Perrotti and Carlos A. Bola{\~n}os and Kwang-Ho Choi and Scott J Russo and Scott G. Edwards and Paula G Ulery and Deanna L Wallace and David W Self and Eric J Nestler and Michel Barrot},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 10},
  pages={2817-24}
}
The transcription factor deltaFosB is induced in the nucleus accumbens and dorsal striatum by chronic exposure to several drugs of abuse, and increasing evidence supports the possibility that this induction is involved in the addiction process. However, to date there has been no report of deltaFosB induction by drugs of abuse in the ventral tegmental area (VTA), which is also a critical brain reward region. In the present study, we used immunohistochemistry to demonstrate that chronic forced… CONTINUE READING
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