DeltaFosB: a sustained molecular switch for addiction.

  title={DeltaFosB: a sustained molecular switch for addiction.},
  author={Eric J Nestler and Michel Barrot and David W Self},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 20},
The longevity of some of the behavioral abnormalities that characterize drug addiction has suggested that regulation of neural gene expression may be involved in the process by which drugs of abuse cause a state of addiction. Increasing evidence suggests that the transcription factor DeltaFosB represents one mechanism by which drugs of abuse produce relatively stable changes in the brain that contribute to the addiction phenotype. DeltaFosB, a member of the Fos family of transcription factors… CONTINUE READING
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