Corpus ID: 28293999

Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity.

@article{Gilbert2007Delta9tetrahydrocannabinolPH,
  title={Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity.},
  author={Glenna L. Gilbert and Hee Jung Kim and Jon J. Waataja and Stanley A Thayer},
  journal={Brain research},
  year={2007},
  volume={1128 1},
  pages={
          61-9
        }
}
  • Glenna L. Gilbert, Hee Jung Kim, +1 author Stanley A Thayer
  • Published in Brain research 2007
  • Medicine
  • Excitotoxic neuronal death underlies many neurodegenerative disorders. Because cannabinoid receptor agonists act presynaptically to inhibit glutamate release, we examined the effects of Win 55212-2, a full agonist at CB(1) receptors, and Delta(9)-tetrahydrocannabinol (THC), a partial agonist, on the survival of neurons exposed to an excitotoxic pattern of synaptic activity. Reducing the extracellular Mg(2+) concentration ([Mg(2+)](o)) to 0.1 mM evoked an aberrant pattern of glutamatergic… CONTINUE READING

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