Delta9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study.

@article{Acquas2001Delta9tetrahydrocannabinolEC,
  title={Delta9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study.},
  author={Elio Acquas and Augusta Pisanu and P Marrocu and Steven R. Goldberg and Gaetano Di Chiara},
  journal={European journal of pharmacology},
  year={2001},
  volume={419 2-3},
  pages={155-61}
}
The intravenous administration of synthetic cannabinoid agonists was recently shown to dose dependently increase acetylcholine release from the rat prefrontal cortex and hippocampus (Eur. J. Pharmacol. 401 (2000) 179]. We report here that the active ingredient of cannabis preparations, delta9-tetrahydrocannabinol, administered at 10, 37.5, 75 and 150 microg/kg, dose dependently stimulated acetylcholine release from rat prefrontal cortex and hippocampus estimated by means of in vivo brain… CONTINUE READING

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