• Corpus ID: 6594480

Delta-tocotrienol augments cisplatin-induced suppression of non-small cell lung cancer cells via inhibition of the Notch-1 pathway.

@article{Ji2012DeltatocotrienolAC,
  title={Delta-tocotrienol augments cisplatin-induced suppression of non-small cell lung cancer cells via inhibition of the Notch-1 pathway.},
  author={Xiangming Ji and Zhiwei Wang and Fazlul H. Sarkar and Smiti Vaid Gupta},
  journal={Anticancer research},
  year={2012},
  volume={32 7},
  pages={
          2647-55
        }
}
Non-small cell lung cancer (NSCLC), accounting for 80% of lung cancers, is the leading cause of all cancer deaths. Previously, we demonstrated that delta-tocotrienol inhibits NSCLC cell proliferation, invasion and induces apoptosis by down-regulation of the Notch-1 signaling pathway. The objective of this study was to investigate whether delta-tocotrienol, could enhance the anticancer effects of cisplatin. Treatment with a combination of delta-tocotrienol and cisplatin resulted in a dose… 
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TLDR
The results suggest that down‐regulation of Notch‐1, via inhibition of NF‐κB signaling pathways by delta‐tocotrienol, could provide a potential novel approach for prevention of tumor progression in non‐small cell lung cancer.
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