Corpus ID: 44642908

Delta subunit inhibits neurosteroid modulation of GABAA receptors.

@article{Zhu1996DeltaSI,
  title={Delta subunit inhibits neurosteroid modulation of GABAA receptors.},
  author={W. Zhu and J. Wang and K. Krueger and S. Vicini},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 21},
  pages={
          6648-56
        }
}
  • W. Zhu, J. Wang, +1 author S. Vicini
  • Published 1996
  • Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
Neurosteroid modulation of GABAA receptors has been observed with all subunit combinations investigated; however, hetero-oligomeric GABAA receptors containing delta subunits were not studied previously. We describe the effect of delta subunit expression on 3alpha,21-dihydroxy-5alpha-pregnan-20-1 (THDOC)-induced potentiation of GABA-gated currents in transfected HEK 293 cells and in cerebellar granule cells in vitro. THDOC (100 nM) significantly potentiated GABA-gated currents in cells… Expand
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