• Medicine
  • Published in
    The Journal of neuroscience…
    1996

Delta subunit inhibits neurosteroid modulation of GABAA receptors.

@article{Zhu1996DeltaSI,
  title={Delta subunit inhibits neurosteroid modulation of GABAA receptors.},
  author={Wenge Zhu and Jian Feng Wang and Karl E. Krueger and Stefano Vicini},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 21},
  pages={
          6648-56
        }
}
Neurosteroid modulation of GABAA receptors has been observed with all subunit combinations investigated; however, hetero-oligomeric GABAA receptors containing delta subunits were not studied previously. We describe the effect of delta subunit expression on 3alpha,21-dihydroxy-5alpha-pregnan-20-1 (THDOC)-induced potentiation of GABA-gated currents in transfected HEK 293 cells and in cerebellar granule cells in vitro. THDOC (100 nM) significantly potentiated GABA-gated currents in cells… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

Exploring the activity of an inhibitory neurosteroid at GABAA receptors

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Neurosteroid prolongs GABAA channel deactivation by altering kinetics of desensitized states.

  • Wenge Zhu, Stefano Vicini
  • Medicine, Biology
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1997
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Probing GABAA receptors with inhibitory neurosteroids

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Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.

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New perspectives in the functional role of GABAa channel heterogeneity

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