Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy.

Abstract

We measured morning plasma concentrations of delta sleep-inducing-peptide-like-immunoreactivity (DSIP-LI) in 9 sleep apnea patients, 10 narcolepsy patients, and 11 normal controls. Comparisons between the three groups showed no significant differences, although there was a trend toward association with low levels of DSIP-LI in the narcoleptic group, particularly in patients not using medications. No differences were found in the morning or evening plasma DSIP-LI levels in a second group of 11 normal controls and 8 sleep apneics. Our findings do not appear to support a biological marker role of disease activity for single measures of plasma DSIP in sleep apnea.

Cite this paper

@article{Vgontzas1995DeltaSP, title={Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy.}, author={Alexandros N. Vgontzas and Theodore C Friedman and George P. Chrousos and Edward O . Bixler and Antonio Vela-Bueno and Anthony Kales}, journal={Peptides}, year={1995}, volume={16 6}, pages={1153-6} }