Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis

@inproceedings{Sidorov2017DeltaRI,
  title={Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis},
  author={Michael S Sidorov and Gina M. Deck and Marjan Dolatshahi and Ronald L Thibert and Lynne M. Bird and C. J. Chu and Benjamin D Philpot},
  booktitle={Journal of Neurodevelopmental Disorders},
  year={2017}
}
Clinicians have qualitatively described rhythmic delta activity as a prominent EEG abnormality in individuals with Angelman syndrome, but this phenotype has yet to be rigorously quantified in the clinical population or validated in a preclinical model. Here, we sought to quantitatively measure delta rhythmicity and evaluate its fidelity as a biomarker. We quantified delta oscillations in mouse and human using parallel spectral analysis methods and measured regional, state-specific, and… CONTINUE READING

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