Delta-like ligand 4 regulates vascular endothelial growth factor receptor 2-driven luteal angiogenesis through induction of a tip/stalk phenotype in proliferating endothelial cells.

@article{GarcaPascual2013DeltalikeL4,
  title={Delta-like ligand 4 regulates vascular endothelial growth factor receptor 2-driven luteal angiogenesis through induction of a tip/stalk phenotype in proliferating endothelial cells.},
  author={Carmen Maria Garc{\'i}a-Pascual and Ralf Zimmermann and Hortensia Ferrero and Carrie J. Shawber and Jan Kitajewski and Carlos Sim{\'o}n and Antonio Pellicer and Ra{\'u}l Aguero G{\'o}mez},
  journal={Fertility and sterility},
  year={2013},
  volume={100 6},
  pages={1768-76.e1}
}
OBJECTIVE To explore whether the Dll4/Notch-1 signaling pathway modulates vascular endothelial growth factor (VEGF)-dependent luteal angiogenesis and related function, by inducing a tip/stalk phenotype in endothelial cells (ECs). DESIGN Experimental laboratory animal study. SETTING University-affiliated infertility center. ANIMAL(S) Immature female mice. INTERVENTION(S) The presence of leading tip ECs in growing luteal vessel was identified by immunofluorescent analysis of Dll4 in the… CONTINUE READING
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Luteal angiogenesis requires Dll 4

  • García-Pascual.
  • Fertil Steril
  • 2013

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