Reverse vaccinology approach for multi-epitope centered vaccine design against delta variant of the SARS-CoV-2
- BiologyEnvironmental Science and Pollution Research
Non-toxic, highly conserved, non-allergenic and highly antigenic B-cell, HTL, and CTL epitopes were identified to minimize adverse effects and maximize the efficacy of chimeric vaccines that could be developed from these epitopes.
E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces
E-Volve, a tool designed to model a structure with a list of mutations requested by users and return analyses of the variant protein, can depict the main alterations in important biological structures, as shown in the SARS-CoV-2 complexes, marking a major step in the real-time tracking of the virus mutant lineages.
Potential inhibitors of SARS-CoV-2 (COVID 19) spike protein of the delta and delta plus variant: In silico studies of medicinal plants of North-East India
- Biology, ChemistryCurrent Research in Pharmacology and Drug Discovery
The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R
This study demonstrates an independent, local emergence of a variant carrying a critical mutation, L452R, which may have the potential of becoming a variant of concern and emphasizes the importance of routine surveillance and detection of novel variants among efforts undertaken to prevent further disease spread.
Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China: a nation-wide study
- MedicineScience China. Life sciences
The COVID-19 epidemic had a significant adverse impact on STEMI in-hospital mortality, with bimodal peaks during early lockdown and early lift periods and clear mortality gradients by timing and types of revascularization procedure, independent of the time periods.
Clinico-Genomic Analysis Reiterates Mild Symptoms Post-vaccination Breakthrough: Should We Focus on Low-Frequency Mutations?
- Medicine, BiologyFrontiers in Microbiology
This study conducted a clinico-genomic study of ChAdOx1 (Covishield) VBT cases in HCWs after complete vaccination to offer insights into low-frequency mutations that could be a modulator of VBT infections.
Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque
- Medicine, BiologyVirologica Sinica
Decontamination of SARS-CoV-2 from cold-chain food packaging provides no marginal benefit in risk reduction to food workers
- MedicineFood Control
A Genomic Snapshot of the SARS-CoV-2 Pandemic in the Balearic Islands
- BiologyFrontiers in Microbiology
Virus evolution, mainly driven by the acquisition and selection of spike substitutions conferring biological advantages, social restrictions, and size population are apparently key factors for explaining the epidemic patterns registered in the Balearic Islands.
PAD Inhibitors as a Potential Treatment for SARS-CoV-2 Immunothrombosis
The clinical significance of PAD-4 inhibitors in reducing thrombotic complications across various inflammatory disorders like COVID-19 and suggests that these inhibitors may be valuable in treating the origin of SARS-CoV-2 immunothrombosis are offered.
Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States
It was showed that B.1.617.2 was growing faster in counties with a lower vaccination rate, which is consistent with reports from other countries and was rapidly being displaced and is no longer responsible for the majority of new cases.