173 Citations
Immunity after COVID-19 Recovery and Vaccination: Similarities and Differences
- Biology, MedicineVaccines
- 2022
The mechanisms of immune response to various types of vaccines (nucleoside-modified, adenovirus-vectored, inactivated virus vaccines and recombinant protein adjuvanted formulations) are discussed and specific aspects of vaccination in selected patient populations with altered immune activity are discussed.
Reverse vaccinology approach for multi-epitope centered vaccine design against delta variant of the SARS-CoV-2
- BiologyEnvironmental Science and Pollution Research
- 2022
Non-toxic, highly conserved, non-allergenic and highly antigenic B-cell, HTL, and CTL epitopes were identified to minimize adverse effects and maximize the efficacy of chimeric vaccines that could be developed from these epitopes.
E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces
- BiologyPeerJ
- 2022
E-Volve, a tool designed to model a structure with a list of mutations requested by users and return analyses of the variant protein, can depict the main alterations in important biological structures, as shown in the SARS-CoV-2 complexes, marking a major step in the real-time tracking of the virus mutant lineages.
PAD Inhibitors as a Potential Treatment for SARS-CoV-2 Immunothrombosis
- BiologyBiomedicines
- 2021
The clinical significance of PAD-4 inhibitors in reducing thrombotic complications across various inflammatory disorders like COVID-19 and suggests that these inhibitors may be valuable in treating the origin of SARS-CoV-2 immunothrombosis are offered.
Potential inhibitors of SARS-CoV-2 (COVID 19) spike protein of the delta and delta plus variant: In silico studies of medicinal plants of North-East India
- Biology, ChemistryCurrent Research in Pharmacology and Drug Discovery
- 2021
The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R
- BiologyVaccines
- 2021
This study demonstrates an independent, local emergence of a variant carrying a critical mutation, L452R, which may have the potential of becoming a variant of concern and emphasizes the importance of routine surveillance and detection of novel variants among efforts undertaken to prevent further disease spread.
Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China: a nation-wide study
- MedicineScience China. Life sciences
- 2022
The COVID-19 epidemic had a significant adverse impact on STEMI in-hospital mortality, with bimodal peaks during early lockdown and early lift periods and clear mortality gradients by timing and types of revascularization procedure, independent of the time periods.
Clinico-Genomic Analysis Reiterates Mild Symptoms Post-vaccination Breakthrough: Should We Focus on Low-Frequency Mutations?
- Medicine, BiologyFrontiers in Microbiology
- 2022
This study conducted a clinico-genomic study of ChAdOx1 (Covishield) VBT cases in HCWs after complete vaccination to offer insights into low-frequency mutations that could be a modulator of VBT infections.
Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque
- Medicine, BiologyVirologica Sinica
- 2022
References
Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States
- MedicinemedRxiv
- 2021
It was showed that B.1.617.2 was growing faster in counties with a lower vaccination rate, which is consistent with reports from other countries and was rapidly being displaced and is no longer responsible for the majority of new cases.