Delta-Aminolaevulinic acid and amino acid neurotransmitters.

  title={Delta-Aminolaevulinic acid and amino acid neurotransmitters.},
  author={Michael W. Brennan and Richard C. Cantrill},
  journal={Molecular and cellular biochemistry},
  volume={38 Spec No Pt 1},
The effects of the porphyrin precursor delta-aminolaevulinic acid (ALA) on gamma-aminobutyric acid (GABA) and L-glutamate transmitter systems was investigated in rat brain. It was found that ALA inhibited GABA and glutamate uptake and stimulated basal efflux of the amino acids in purified nerve endings. These effects were evident only at relatively high concentrations of ALA (at least 100 microM). Such concentrations probably do not occur in the nervous systems of patients suffering from acute… CONTINUE READING


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