Delta(9)-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline.

Abstract

RATIONALE The results of recent in vitro studies have underscored the important role that activation of CB(1) receptors has on GABAergic activity in brain areas associated with memory. OBJECTIVES The primary purpose of this study was to test the hypothesis that the memory disruptive effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in vivo are… (More)

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@article{Varvel2005Delta9THCinducedCD, title={Delta(9)-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline.}, author={S A Varvel and Emmanuel A. Anum and Floride Niyuhire and Laura E. Wise and Aron H. Lichtman}, journal={Psychopharmacology}, year={2005}, volume={178 2-3}, pages={317-27} }