Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue.


Omega-6 (n-6) arachidonic acid (AA) and its pro-inflammatory metabolites, including prostaglandin E2 (PGE(2)), are known to promote tumorigenesis. Delta-6 desaturase (D6D) is the rate-limiting enzyme for converting n-6 linoleic acid (LA) to AA. Our objective was to determine if AA synthesis, specifically D6D activity, and PGE(2) levels are increased in… (More)
DOI: 10.1111/cas.12129


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics