Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men.

@article{Jasuja2005Delta4androstene317dioneBA,
  title={Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men.},
  author={R. Jasuja and Pandurangan Ramaraj and Ricky Phong Mac and Atam B Singh and Thomas Storer and Jorge Artaza and Aria M Miller and Rajan Singh and W. Edgar Taylor and Martin Laurence Lee and Tina Davidson and Indrani Sinha-Hikim and N{\'e}stor Gonz{\'a}lez-Cadavid and Shalender Bhasin},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 2},
  pages={855-63}
}
Previous studies of Delta 4-androstene-3,17-dione (4-androstenedione) administration in men have not demonstrated sustained increments in testosterone levels, fat-free mass (FFM), and muscle strength, and failure to demonstrate androstenedione's androgenic/anabolic effects has stifled efforts to regulate its sales. To determine whether 4-androstenedione has androgenic/anabolic properties, we evaluated its association with androgen receptor (AR) and its effects on myogenesis in vitro… CONTINUE READING

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