Delta(9)-tetrahydrocannabinol selectively increases aspartyl cathepsin D proteolytic activity and impairs lysozyme processing by macrophages.

Abstract

Delta(9)-tetrahydrocannabinol (THC) causes an antigen-dependent defect in the ability of macrophages to activate helper T cells, and this drug-induced impairment is mediated through the peripheral CB2 receptor. Various requirements for the processing of the antigen, lysozyme, were examined to determine where along the pathway THC exerts its influence. A THC… (More)

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@article{Matveyeva2000Delta9tetrahydrocannabinolSI, title={Delta(9)-tetrahydrocannabinol selectively increases aspartyl cathepsin D proteolytic activity and impairs lysozyme processing by macrophages.}, author={M Matveyeva and Constance B Hartmann and M T Harrison and Gonçalo Cabral and Kelly L. McCoy}, journal={International journal of immunopharmacology}, year={2000}, volume={22 5}, pages={373-81} }