Delphinidin and cyanidin exhibit antiproliferative and apoptotic effects in MCF7 human breast cancer cells

  title={Delphinidin and cyanidin exhibit antiproliferative and apoptotic effects in MCF7 human breast cancer cells},
  author={Jessica Tang and E. Oroudjev and L. Wilson and George Ayoub},
Fruits high in antioxidants such as berries and pomegranates have been shown to have many biological effects, including anticancer activity. We previously reported that bilberry (European blueberry) extract exhibited cytotoxic effects on MCF7-GFP-Tubulin breast cancer cells. To delve further into the mechanism of action of bilberry extract, we focused on two of the most abundant anthocyanins found in bilberry, delphinidin and cyanidin. In this study, we examined the radical scavenging activity… Expand

Figures from this paper

Potential Role of Phytochemicals Against Matrix Metalloproteinase Induced Breast Cancer; An Explanatory Review
The potential implications of phytochemicals in the management of breast cancer which could lessen the growing encumbrance of disease are underscored. Expand
Flavonoids in Cancer and Apoptosis
A summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed and their high bioavailability, safety, minimal side effects and cost effectiveness are discussed. Expand
Breast Cancer and Flavonoids as Treatment Strategy
The current chapter emphasizes the therapeutic potential of flavonoids and their synthetic analogues as anti-cancer agents in breast cancer providing new insights into the molecular mechanisms. Expand
Bioactive Phytochemicals and Antioxidant Properties of the Grains and Sprouts of Colored Wheat Genotypes
The correlation results between antioxidant activity and contents of bioactive phytochemicals in grains and sprouts of colored wheat genotypes have shown a high correlation for cyanidin and pelargonidin, especially in grains, as well as quercetin in sprouts. Expand
The Impact of O-Glycosylation on Cyanidin Interaction with RBCs and HMEC-1 Cells—Structure–Activity Relationships
Cyanidin and its O-glycosides effectively protect erythrocytes against free radicals and affect intracellular reactive oxygen spices (ROS) generation under physiological and AAPH-induced oxidative stress conditions and suggest a potential beneficial effect of cyanidin on the cardiovascular system. Expand
A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes
The potential application of these naturally occurring SIRT6 modulators in the amelioration of major human diseases such as Alzheimer’s disease, aging, diabetes, inflammation, and cancer has been delineated. Expand
Evaluation of Anthocyanin Content, Antioxidant Potential and Antimicrobial Activity of Black, Purple and Blue Colored Wheat Flour and Wheat-Grass Juice against Common Human Pathogens
The present study aimed to analyze the antioxidant and antimicrobial activity of anthocyanins extracted from colored wheat flour and wheat-grass juice against human pathogens, finding that anthOCyanin-rich colored wheat could be of nutraceutical importance. Expand


Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins.
Results indicate that the bilberry extract and the anthocyanins, bearing delphinidin or malvidin as the aglycon, inhibit the growth of HL60 cells through the induction of apoptosis. Expand
Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells.
It is concluded that bilberry extract as ingested by humans, not just the purified anthocyanins it contains, inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis. Expand
Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines
Flavonoids of the flavone, flavonol, flavanone, and isoflavone classes possess antiproliferative effects in different cancer cell lines. Expand
Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells.
The effect of HAs on human cancer cells was explored and it was suggested that HAs mediated HL-60 apoptosis via the p38-FasL and Bid pathway and could be developed as chemopreventive agents. Expand
Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth.
The varying compositions and degrees of growth inhibition suggest that the anthocyanin chemical structure may play an important role in the growth inhibitory activity of commercially available AREs. Expand
Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables.
This is the first report of tumor cell proliferation inhibitory activity by anthocyanidins, and cyanidin, delphinidin and petunidin inhibited the breast cancer cell growth by 47, 66 and 53%, respectively. Expand
The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor.
The anthocyanidins cy and del are potent inhibitors of the EGFR, shutting off downstream signaling cascades, which might contribute substantially to the growth-inhibitory properties of these natural food constituents. Expand
Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines.
The different effects exerted by DP as compared with CY suggest that the presence of the three hydroxyl groups on the beta ring in the molecular structure of DP may be important for its greater biological activity. Expand
Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells.
  • Ping-Hsiao Shih, C. Yeh, G. Yen
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2005
Findings suggest that growth inhibition and cytotoxicity of AGS cells by malvidin is involved in the induction of apoptosis rather than necrosis. Expand
Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.
The data provided by the current study and from other laboratories warrants further investigation into the chemopreventive and chemotherapeutic effects of berries using in vivo models. Expand