Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I.

@article{Takasawa2010DelphinidinAD,
  title={Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I.},
  author={Ryoko Takasawa and Kazunori Saeki and Akinobu Tao and Atsushi Yoshimori and Hiromi Uchiro and Mutsunori Fujiwara and Sei-ichi Tanuma},
  journal={Bioorganic & medicinal chemistry},
  year={2010},
  volume={18 19},
  pages={7029-33}
}
Glyoxalase I (GLO I) is the rate-limiting enzyme for detoxification of methylglyoxal (MG), a side-product of glycolysis, which is able to induce apoptosis. Since GLO I is known to be highly expressed in the most tumor cells and little in normal cells, inhibitors of this enzyme has been expected to be new anticancer drugs. Here, we examined the inhibitory… CONTINUE READING