Delivery of zoledronic acid encapsulated in folate-targeted liposome results in potent in vitro cytotoxic activity on tumor cells.

@article{Shmeeda2010DeliveryOZ,
  title={Delivery of zoledronic acid encapsulated in folate-targeted liposome results in potent in vitro cytotoxic activity on tumor cells.},
  author={Hilary Shmeeda and Yasmine Amitay and Jenny Gorin and Dina Tzemach and Lidia Mak and Joerge Ogorka and Saran Kumar and Jing A. Zhang and Alberto Gabizon},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2010},
  volume={146 1},
  pages={76-83}
}
INTRODUCTION Zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, is a potent inhibitor of farnesyl-pyrophosphate synthase with poor in vitro cytotoxic activity as a result of its limited diffusion into tumor cells. The purpose of this study was to investigate whether liposomes targeted to the folate receptor (FR) can effectively deliver ZOL to tumor cells and enhance its in vitro cytotoxicity. METHODS ZOL was entrapped in the water phase of liposomes of various compositions with or… CONTINUE READING

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