Delivery of therapeutic siRNA to the lung endothelium via novel Lipoplex formulation DACC.

@article{Fehring2014DeliveryOT,
  title={Delivery of therapeutic siRNA to the lung endothelium via novel Lipoplex formulation DACC.},
  author={Volker Fehring and Ute Schaeper and Katharina Ahrens and Ansgar Santel and Oliver Keil and Mona Eisermann and Klaus Willi Giese and Joerg Kaufmann},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2014},
  volume={22 4},
  pages={
          811-20
        }
}
Posttranscriptional gene silencing by RNA interference can be therapeutically exploited to inhibit pathophysiological gene expression. However, in contrast to the established effectiveness of RNAi in vitro, safe and effective delivery of siRNAs to specific organs and cell types in vivo remains the major hurdle. Here, we report the development and in vivo characterization of a novel siRNA delivery system (DACC lipoplex) suitable for modulating target gene expression specifically in the lung… CONTINUE READING
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Lipid nanoparticles for short interfering RNA delivery.

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Delivery of siRNA to the mouse lung via a functionalized lipopolyamine.

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