Delivery of theophylline into excised human skin from alkanoic acid solutions: a "push-pull" mechanism.

@article{Kadir1987DeliveryOT,
  title={Delivery of theophylline into excised human skin from alkanoic acid solutions: a "push-pull" mechanism.},
  author={R. Kadir and D Stempler and Z Liron and Seth Cohen},
  journal={Journal of pharmaceutical sciences},
  year={1987},
  volume={76 10},
  pages={774-9}
}
Human skin samples are permeable to theophylline delivered from 1.5% solutions in various alkanecarboxylic acids and their mixtures. The respective permeability coefficients of theophylline, calculated from steady-state flux, correlate negatively with the permeability coefficients of the donor carboxylic acids and positively with the excess free energy of theophylline in the donor phase, or "push" effect. An exception is propionic acid which enhances the penetration of theophylline by promoting… CONTINUE READING