Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules.

@article{Adams2000DeliveryOT,
  title={Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules.},
  author={Gregory P. Adams and Calvin C. Shaller and Lara L Chappell and Chuanchu Wu and Eva M. Horak and Heidi H. Simmons and Samuel Litwin and James D Marks and Louis M. Weiner and Martin W. Brechbiel},
  journal={Nuclear medicine and biology},
  year={2000},
  volume={27 4},
  pages={339-46}
}
Intravenously administered anti-tumor single-chain Fv (scFv) and diabody molecules exhibit rapid clearance kinetics and accumulation in tumors that express their cognate antigen. In an attempt to fit the rate of isotope decay to the timing of delivery and duration of tumor retention, anti-HER2/neu CHX-A" DTPA-C6.5K-A scFv and diabody conjugates were labeled with the alpha-particle emitter (213)Bi (t(1/2) = 47 min). Radioimmunotherapy studies employing 0.64, 0.35, or 0.15 microCi of (213)Bi… CONTINUE READING