Delivery of rifampicin-PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis.

@article{Hirota2010DeliveryOR,
  title={Delivery of rifampicin-PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis.},
  author={Keiji Hirota and Taizo Hasegawa and Takehisa Nakajima and Hiroyuki Inagawa and Chie Kohchi and Gen-ichiro Soma and K. Makino and Hiroshi Terada},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2010},
  volume={142 3},
  pages={339-46}
}
Inhalation delivery of poly(lactic-co-glycolic) acid (PLGA) microspheres (MS) loaded with the anti-tuberculosis agent rifampicin (RFP-PLGA MS) to alveolar macrophage (M phi) cells could be an effective drug delivery system for the treatment of tuberculosis. To examine this possibility, we studied (1) the bactericidal effect of RFP-PLGA MS on Mycobacterium bovis Bacillus Calmette-Guérin (BCG)-infected rat alveolar M phi NR8383 cells, and (2) changes in the biochemical events induced in these… CONTINUE READING