Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery

@article{Haidar2009DeliveryOR,
  title={Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery},
  author={Ziyad S Haidar and Reggie Charles Hamdy and Maryam Tabrizian},
  journal={Biotechnology Letters},
  year={2009},
  volume={31},
  pages={1817-1824}
}
Recombinant human bone morphogenetic proteins (rhBMPs) have been extensively investigated for developing therapeutic strategies aimed at the restoration and treatment of orthopaedic as well as craniofacial conditions. In this first part of the review, we discuss the rationale for the necessary use of carrier systems to deliver rhBMP-2 and rhBMP-7 to sites of bone tissue regeneration and repair. General requirements for growth factor delivery systems emphasizing the distinction between localized… CONTINUE READING
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