Delivery of ofloxacin to the lung and alveolar macrophages via hyaluronan microspheres for the treatment of tuberculosis.

Abstract

Microspheres containing ofloxacin (HMO) with a mean diameter of 2-5 mum were prepared by the co-spray drying of ofloxacin and the sodium salt of hyaluronic acid (hyaluronan). Recovery of lactose blends of HMO from stage II of the twin-stage impinger (TSI) reached 43%, indicating favorable delivery of the drug to the lung via inhalation. The area under the… (More)
DOI: 10.1016/j.jconrel.2008.04.009

Topics

Cite this paper

@article{Hwang2008DeliveryOO, title={Delivery of ofloxacin to the lung and alveolar macrophages via hyaluronan microspheres for the treatment of tuberculosis.}, author={S. M. Hwang and D D Kim and S. J. Chung and Changsub Shim}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2008}, volume={129 2}, pages={100-6} }