Delivery of interferon-beta to the monkey nervous system following intranasal administration.

  title={Delivery of interferon-beta to the monkey nervous system following intranasal administration.},
  author={Robert G. Thorne and Leah Hanson and Tinna M Ross and David Tung and William H. Frey},
  volume={152 3},
We determined the nervous system targeting of interferon-beta1b (IFN-beta1b), a 20 kDa protein used to treat the relapsing-remitting form of multiple sclerosis, following intranasal administration in anesthetized, adult cynomolgus monkeys. Five animals received an intranasal bolus of [(125)I]-labeled IFN-beta1b, applied bilaterally to the upper nasal passages. Serial blood samples were collected for 45 min, after which the animals were euthanized by transcardial perfusion-fixation. High… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 52 extracted citations


Publications referenced by this paper.
Showing 1-10 of 79 references

Biopharmaceutical benchmarks 2006

  • G alsh
  • Nat Biotechnol
  • 2006

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype

  • MA eger, GS Watson, +9 authors S Craft
  • Neurobiol Aging 27:451–458
  • 2006

Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

  • R e Rosa, AA Garcia, +4 authors A Cattaneo
  • Proc Natl Acad Sci U S A 102:3811–3816
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…