Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model.

@article{Abrahams2001DeliveryOH,
  title={Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model.},
  author={John M. Abrahams and Mark S. Forman and Michael S Grady and Scott L. Diamond},
  journal={AJNR. American journal of neuroradiology},
  year={2001},
  volume={22 7},
  pages={1410-7}
}
BACKGROUND AND PURPOSE Histopathologic studies indicate that aneurysms treated with Guglielmi detachable coils (GDCs) have avascular centers with fibrosis mostly at the aneurysm periphery. We hypothesized that vascular endothelial growth factor (VEGF) released from a coil promotes clot organization, hyperplasia, and endothelial proliferation to facilitate closure of the aneurysm neck. METHODS GDC segments were inserted into ligated common carotid arteries (CCAs) of adult male rats for 14 days… CONTINUE READING
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In vitro proliferation and adhesion of basic fibroblast growth factor-producing fibroblasts on platinum coils

  • DF Kallmes, MK Borland, +4 authors GA. Helm
  • Radiology
  • 1998
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