Delivery of growth factor-associated genes to mesenchymal stem cells for cartilage and bone tissue regeneration

@inproceedings{Ahn2014DeliveryOG,
  title={Delivery of growth factor-associated genes to mesenchymal stem cells for cartilage and bone tissue regeneration},
  author={Jongchan Ahn and Seah Park and Byung-Hyun Cha and J H Kim and Hansoo Park and Yoon Ki Joung and Inbo Han and Soo-Hong Lee},
  year={2014}
}
Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone… CONTINUE READING

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