Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol.

@article{Cao2002DeliveryOE,
  title={Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol.},
  author={Huyen L Cao and Deepak Agrawal and Nicholas Kushner and Neal Y. Touzjian and Max Essex and Yichen Lu},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={185 2},
  pages={244-51}
}
A fragment of anthrax lethal factor possesses the interesting function of delivering recombinant protein antigens through the classical major histocompatibility complex (MHC) class I pathway. This region of the lethal factor lacks the domain associated with anthrax cytotoxicity and functions independently of its binary partner, protective antigen. Experiments that used inhibitors at different steps of the MHC class I pathway supported this hypothesis. Application of this discovery to current T… CONTINUE READING

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