Delivery of drugs , proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis

@inproceedings{Wagner1993DeliveryOD,
  title={Delivery of drugs , proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis},
  author={Ernst Wagner and David A Curiel and Matt Cotten},
  year={1993}
}
Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptormediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and on many kinds of tumors. The efficient cellular mechanism for uptake of transferrin has been subverted for the delivery of low-molecular-weight drugs, protein toxins, and liposomes by linkage of these agents to transferrin or to anti-transferrin… CONTINUE READING

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