Delivery of doxorubicin-loaded PLGA nanoparticles into U87 human glioblastoma cells.

Abstract

The paramount problem in the therapy of brain tumors is the inability of most drugs to cross the blood-brain barrier. PLGA nanoparticles overcoated with poloxamer 188 could overcome this problem and enabled a high anti-tumoral effect against the very aggressive intracranial 101.8 glioblastoma in rats that closely resembles human grade IV glioblastomas. The… (More)
DOI: 10.1016/j.ijpharm.2017.03.049

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