Delivery of celecoxib for treating diseases of the eye: influence of pigment and diabetes.

@article{Amrite2010DeliveryOC,
  title={Delivery of celecoxib for treating diseases of the eye: influence of pigment and diabetes.},
  author={Aniruddha C. Amrite and Vidya Pugazhenthi and Narayan P. S. Cheruvu and Uday B. Kompella},
  journal={Expert opinion on drug delivery},
  year={2010},
  volume={7 5},
  pages={631-45}
}
IMPORTANCE OF THE FIELD Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are two major causes of blindness. In these disorders, growth factors such as vascular endothelial growth factor (VEGF) are upregulated, leading to either enhanced vascular permeability or proliferation of endothelium. While corticosteroid therapies available at present suffer from side effects including cataracts and elevated intraocular pressure, anti-VEGF antibody therapies require frequent… CONTINUE READING