Delivery of a growth factor fusion protein having collagen-binding activity to wound tissues.

@article{Ishikawa2003DeliveryOA,
  title={Delivery of a growth factor fusion protein having collagen-binding activity to wound tissues.},
  author={Tetsuya Ishikawa and Hiroshi Terai and Takashi Yamamoto and Kazumichi Harada and Takashi Kitajima},
  journal={Artificial organs},
  year={2003},
  volume={27 2},
  pages={147-54}
}
Recently, we established a collagen-binding growth factor consisting of epidermal growth factor and the fibronectin collagen-binding domain (FNCBD-EGF). FNCBD-EGF is a biologically active fusion protein that could stably bind to collagen materials, and exert its growth factor activity even after collagen binding. In this study, we investigated the concept that FNCBD moiety with high collagen affinity may enhance the effective local concentration of EGF at the site of administration in the… CONTINUE READING