Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment.

Abstract

Salmonella Typhi, an exclusive human pathogen and the cause of typhoid fever, expresses a functional cytolethal distending toxin for which only the active subunit, CdtB, has been identified. Here, we show that PltA and PltB, which are encoded in the same pathogenicity islet as cdtB, associate with CdtB to form a multipartite toxin. PltA and PltB are… (More)
DOI: 10.1016/j.chom.2007.11.001

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