Delivery of Non-Native Cargo into Mammalian Cells Using Anthrax Lethal Toxin.

@article{Rabideau2016DeliveryON,
  title={Delivery of Non-Native Cargo into Mammalian Cells Using Anthrax Lethal Toxin.},
  author={Amy Ellen Rabideau and Bradley L Pentelute},
  journal={ACS chemical biology},
  year={2016},
  volume={11 6},
  pages={
          1490-501
        }
}
The intracellular delivery of peptide and protein therapeutics is a major challenge due to the plasma membrane, which acts as a barrier between the extracellular environment and the intracellular milieu. Over the past two decades, a nontoxic PA/LFN delivery platform derived from anthrax lethal toxin has been developed for the transport of non-native cargo into the cytosol of cells in order to understand the translocation process through a protective antigen (PA) pore and to probe intracellular… CONTINUE READING
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