Delivery of CdiA Nuclease Toxins into Target Cells during Contact-Dependent Growth Inhibition

@inproceedings{Webb2013DeliveryOC,
  title={Delivery of CdiA Nuclease Toxins into Target Cells during Contact-Dependent Growth Inhibition},
  author={Julia Sanchez Webb and Kiel C. Nikolakakis and Julia L E Willett and Stephanie K. Aoki and Christopher S Hayes and David A. Low},
  booktitle={PloS one},
  year={2013}
}
Bacterial contact-dependent growth inhibition (CDI) is mediated by the CdiB/CdiA family of two-partner secretion proteins. CDI systems deploy a variety of distinct toxins, which are contained within the polymorphic C-terminal region (CdiA-CT) of CdiA proteins. Several CdiA-CTs are nucleases, suggesting that the toxins are transported into the target cell cytoplasm to interact with their substrates. To analyze CdiA transfer to target bacteria, we used the CDI system of uropathogenic Escherichia… CONTINUE READING
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