Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.

@article{Osicka2000DeliveryOC,
  title={Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.},
  author={Radim Osicka and Adriana Osickova and Tumay Basar and Pierre Guermonprez and M. I Vergara Rojas and Catherine Michaud Leclerc and Peter {\vS}ebo},
  journal={Infection and immunity},
  year={2000},
  volume={68 1},
  pages={
          247-56
        }
}
Bordetella pertussis adenylate cyclase (AC) toxin-hemolysin (ACT-Hly) can penetrate a variety of eukaryotic cells. Recombinant AC toxoids have therefore been recently used for delivery of CD8(+) T-cell epitopes into antigen-presenting cells in vivo and for induction of protective antiviral, as well as therapeutic antitumor cytotoxic T-cell responses. We have explored the carrier potential of the ACT molecule by insertional mutagenesis scanning for new permissive sites, at which integration of… CONTINUE READING

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