Delivering the goods: viral and non-viral gene therapy systems and the inherent limits on cargo DNA and internal sequences

@article{Atkinson2009DeliveringTG,
  title={Delivering the goods: viral and non-viral gene therapy systems and the inherent limits on cargo DNA and internal sequences},
  author={Helen Atkinson and Ronald Chalmers},
  journal={Genetica},
  year={2009},
  volume={138},
  pages={485-498}
}
Viruses have long been considered to be the most promising tools for human gene therapy. However, the initial enthusiasm for the use of viruses has been tarnished in the light of potentially fatal side effects. Transposons have a long history of use with bacteria in the laboratory and are now routinely applied to eukaryotic model organisms. Transposons show promise for applications in human genetic modification and should prove a useful addition to the gene therapy tool kit. Here we review the… CONTINUE READING