Delivering mesenchymal stem cells in collagen microsphere carriers to rabbit degenerative disc: reduced risk of osteophyte formation.

@article{Li2014DeliveringMS,
  title={Delivering mesenchymal stem cells in collagen microsphere carriers to rabbit degenerative disc: reduced risk of osteophyte formation.},
  author={Yuk Yin Li and Hua Jia Diao and Tze Kit Chik and Cin Ting Chow and Xiao Meng An and Victor K. L Leung and Kenneth Man Chi Cheung and Barbara P Chan},
  journal={Tissue engineering. Part A},
  year={2014},
  volume={20 9-10},
  pages={1379-91}
}
Mesenchymal stem cells (MSCs) have the potential to treat early intervertebral disc (IVD) degeneration. However, during intradiscal injection, the vast majority of cells leaked out even in the presence of hydrogel carrier. Recent evidence suggests that annulus puncture is associated with cell leakage and contributes to osteophyte formation, an undesirable side effect. This suggests the significance of developing appropriate carriers for intradiscal delivery of MSCs. We previously developed a… CONTINUE READING
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