Delineation of the peptide binding site of the human galanin receptor.

  title={Delineation of the peptide binding site of the human galanin receptor.},
  author={Kalev Kask and Malin Berthold and Ulrika Kahl and Gunnar Nordvall and Tamas Bartfai},
  journal={The EMBO journal},
  volume={15 2},
Galanin, a neuroendocrine peptide of 29 amino acids, binds to Gi/Go-coupled receptors to trigger cellular responses. To determine which amino acids of the recently cloned seven-transmembrane domain-type human galanin receptor are involved in the high-affinity binding of the endogenous peptide ligand, we performed a mutagenesis study. Mutation of the His264 or His267 of transmembrane domain VI to alanine, or of Phe282 of transmembrane domain VII to glycine, results in an apparent loss of galanin… CONTINUE READING

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Huang,R.R. and Strader.C.D

  • T. M. Fong, Yu
  • Biocheniistry
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