Delineation of the molecular mechanisms of nucleoside recognition by cytidine deaminase through virtual screening.

Abstract

Cytidine deaminase (EC 3.5.4.5, CDA), an enzyme of the pyrimidine salvage pathways, is responsible for the degradation and inactivation of several cytidine-based antitumor drugs such as cytarabine, gemcitabine, decitabine, and azacytidine. Thus, CDA inhibitors are highly sought after as compounds to be co-administered with said drugs to improve their… (More)
DOI: 10.1002/cmdc.201100139

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