Delineation of the mechanism of inhibition of human T cell activation by PGE2.

@article{Minakuchi1990DelineationOT,
  title={Delineation of the mechanism of inhibition of human T cell activation by PGE2.},
  author={R Minakuchi and Mary C. Wacholtz and Laurie S. Davis and Peter E Lipsky},
  journal={Journal of immunology},
  year={1990},
  volume={145 8},
  pages={2616-25}
}
The capacity of PGE2 to inhibit human T cell responses was examined by investigating its effect on mitogen-induced IL-2 production and proliferation of highly purified CD4+ T cells. PGE2 inhibited both PHA and anti-CD3 induced proliferation and IL-2 production by an action directly on the responding T cell. Inhibition of IL-2 production reflected decreased accumulation of mRNA for IL-2. A variety of other cAMP elevating agents exerted similar inhibitory effects. Inhibition of proliferation… CONTINUE READING

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