Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system.

@article{Dietzschold1992DelineationOP,
  title={Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system.},
  author={Bernhard Dietzschold and M. L. Kao and Yu Mei Zheng and Zheng Yi Chen and G. Maul and Zhen Fu and Charles E. Rupprecht and Hilary Koprowski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 15},
  pages={7252-6}
}
The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was related to the mAb's ability to inhibit virus spread from cell to cell and to restrict rabies virus RNA transcription. Since treatment of rabies virus-infected cells with virus… CONTINUE READING