Delineation of biological and molecular mechanisms underlying the diverse anticancer activities of mycophenolic acid.

@article{Dun2013DelineationOB,
  title={Delineation of biological and molecular mechanisms underlying the diverse anticancer activities of mycophenolic acid.},
  author={Boying Dun and Heng Yu Xu and Ashok Sharma and Haitao Liu and Hongfang Yu and Bing Yi and Xiaoxin Liu and Mingfang He and Lingwen Zeng and Jin-Xiong She},
  journal={International journal of clinical and experimental pathology},
  year={2013},
  volume={6 12},
  pages={
          2880-6
        }
}
BACKGROUND Mycophenolate mofetil (MMF), the prodrug of mycophenolic acid (MPA) which has been widely used for the prevention of acute graft rejection, is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH) that is up-regulated in many tumors and potentially a target for cancer therapy. MPA is known to inhibit cancer cell proliferation and induces apoptosis; however, the underlying molecular mechanisms remain elusive. METHODS We first demonstrated MPA's antiproliferative and… CONTINUE READING
1
Twitter Mention

References

Publications referenced by this paper.
SHOWING 1-10 OF 23 REFERENCES

Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11.

Xiao-Xin Sun, Mu-Shui Dai, Hua Lu
  • The Journal of biological chemistry
  • 2008
VIEW 2 EXCERPTS

Similar Papers

Loading similar papers…