Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells.

@article{Damelin2011DelineationOA,
  title={Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells.},
  author={Marc Damelin and Kenneth G Geles and Maximillian T. Follettie and Ping Yuan and Michelle Baxter and Jonathon Golas and John F Dijoseph and Maha A Karnoub and Shuguang Huang and Veronica Diesl and Carmen Behrens and Sung E. Choe and Carol Rios and Janet Gruzas and Latha Sridharan and Maureen M. Dougher and Arthur Kunz and Philip R. Hamann and Deborah J. Evans and Douglas C. Armellino and Kiran M. Khandke and Kimberly Marquette and Lioudmila Tchistiakova and Erwin R. Boghaert and Robert T. Abraham and Ignacio Wistuba and B S Zhou},
  journal={Cancer research},
  year={2011},
  volume={71 12},
  pages={4236-46}
}
Poorly differentiated tumors in non-small cell lung cancer (NSCLC) have been associated with shorter patient survival and shorter time to recurrence following treatment. Here, we integrate multiple experimental models with clinicopathologic analysis of patient tumors to delineate a cellular hierarchy in NSCLC. We show that the oncofetal protein 5T4 is expressed on tumor-initiating cells and associated with worse clinical outcome in NSCLC. Coexpression of 5T4 and factors involved in the… CONTINUE READING

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Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of on June 5, 2017

  • J. F. DiJoseph, D. C. Armellino, +12 authors N. K. Damle
  • Author Manuscript Published OnlineFirst on May
  • 2011
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