• Corpus ID: 42814009

Delineation of IL-5 domains predicted to engage the IL-5 receptor complex.

@article{Dickason1996DelineationOI,
  title={Delineation of IL-5 domains predicted to engage the IL-5 receptor complex.},
  author={R. R. Dickason and Marilyn M. Huston and David P. Huston},
  journal={Journal of immunology},
  year={1996},
  volume={156 3},
  pages={
          1030-7
        }
}
IL-5 is an interdigitating homodimeric glycoprotein and a member of the helical bundle family of cytokines. IL-5 is a potent activator of eosinophils and a specific promoter of their differentiation. This activity has implicated IL-5 in the pathogenesis of asthma and allergic disease. A detailed understanding of IL-5 structure and function is required to develop immunomodulators of IL-5-mediated inflammatory responses. We generated a panel of neutralizing anti-IL-5 mAbs which were used to map… 
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