Delineating an epigenetic continuum in head and neck cancer.

  title={Delineating an epigenetic continuum in head and neck cancer.},
  author={M. P. H. Harry Holden Gerald Jones Felicia Perry Caro Trosclair and Josena Kunjoonju Stephen and Kang Mei Chen and Shaleta Havard and Veena V Shah and Glendon Michael Gardner and Vanessa Gayl Schweitzer},
  journal={Cancer letters},
  volume={342 2},
A tissue field of somatic genetic alterations precedes the histopathological phenotypic changes of carcinoma. Genomic changes could be of potential use in the diagnosis and prognosis of pre-invasive squamous head and neck carcinoma (HNSCC) lesions and as markers for cancer risk assessment. Studies of sequential molecular alterations and genetic progression of pre-invasive HNSCC have not been clearly defined. Studies have shown recurring alterations at chromosome 9p21 (location of the CDKN2A… CONTINUE READING