Delineating Slowly and Rapidly Evolving Fractions of the Drosophila Genome

@article{Keith2008DelineatingSA,
  title={Delineating Slowly and Rapidly Evolving Fractions of the Drosophila Genome},
  author={Jonathan M. Keith and Peter Adams and Stuart Stephen and John S. Mattick},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2008},
  volume={15 4},
  pages={407-30}
}
Evolutionary conservation is an important indicator of function and a major component of bioinformatic methods to identify non-protein-coding genes. We present a new Bayesian method for segmenting pairwise alignments of eukaryotic genomes while simultaneously classifying segments into slowly and rapidly evolving fractions. We also describe an information criterion similar to the Akaike Information Criterion (AIC) for determining the number of classes. Working with pairwise alignments enables… CONTINUE READING

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