Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice.

@article{Yang2013DeliberateRO,
  title={Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice.},
  author={Chen Yang and Steven Skiena and Bruce Futcher and Steffen Mueller and Eckard J Wimmer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 23},
  pages={9481-6}
}
A long-held dogma posits that strong presentation to the immune system of the dominant influenza virus glycoprotein antigens neuraminidase (NA) and hemagglutinin (HA) is paramount for inducing protective immunity against influenza virus infection. We have deliberately violated this dogma by constructing a recombinant influenza virus strain of A/PR8/34 (H1N1) in which expression of NA and HA genes was suppressed. We down-regulated NA and HA expression by recoding the respective genes with… CONTINUE READING
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Transdermal in fl uenza immunization with vaccinecoated microneedle arrays

DG Koutsonanos
PLoS ONE • 2009

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