Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill

  title={Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill},
  author={James Bartlett and M. Brunner and K. Gough},
  journal={Emergency Medicine Journal},
  pages={159 - 160}
  • James Bartlett, M. Brunner, K. Gough
  • Published 2010
  • Medicine
  • Emergency Medicine Journal
  • A 46-year-old man took a lethal dose of an agent called dinitrophenol (DNP). He presented 11 h after ingestion with loin pain, diarrhoea and vomiting. He rapidly deteriorated with profound hyperthermia, acute renal failure, hyperkalaemia, metabolic acidosis and eventually haemodynamic instability. Despite aggressive supportive measures and rapid sequence induction, he deteriorated and died 21 h after ingestion. DNP is a metabolic poison that acts by uncoupling oxidative phosphorylation, leading… CONTINUE READING
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