Delgocitinib: First Approval

@article{Dhillon2020DelgocitinibFA,
  title={Delgocitinib: First Approval},
  author={Sohita Dhillon},
  journal={Drugs},
  year={2020},
  volume={80},
  pages={609-615}
}
Delgocitinib, a janus kinase (JAK) inhibitor, is being developed by Japan Tobacco for the treatment of autoimmune disorders and hypersensitivity, including inflammatory skin conditions. The JAK family of tyrosine kinases plays an important role in mediating the biological effects of several inflammatory cytokines, e.g. IL-4, IL-13 and IL-31, which are elevated in patients with atopic dermatitis. Delgocitinib inhibits all members of the JAK family [JAK1, JAK2, JAK3 and tyrosine kinase 2… 
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TLDR
The most prevalent treatment-emergent adverse events from oral JAK inhibitor use in AD were nausea, upper respiratory tract infection, headache, herpes zoster, herpes simplex, acne, increased blood creatine phosphokinase levels, and decreased platelet counts.
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Short-term data suggest that both topical and oral JAK inhibitors are efficacious and safe for use in patients with AD, although cases of thrombosis and viral disease have been reported.
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Jakinibs that are approved or are under late phase investigation are reviewed, focusing on clinical applications, pharmacokinetic and safety profiles, and future opportunities and challenges.
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Although topical JAK inhibitors have promising efficacy and safety profiles, poor medication adherence common to topical treatments may limit their utility in a clinical setting.
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Ruxolitinib cream was highly effective at ameliorating disease symptoms in multiple murine dermatitis models through downregulation of T helper (Th)2-driven inflammation, resulting in reduced skin thickening and decreased itch.
JAK3 inhibitors for the treatment of inflammatory and autoimmune diseases: a patent review (2016–present)
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A comprehensive review of the available patent literature on JAK-family inhibitors published from 2016 to the present found that selective JAK3 inhibitors may offer valid, interesting, and promising therapeutic potential in inflammatory and autoimmune diseases.
JAK inhibitors in the treatment of atopic dermatitis
The inhibition of the Janus kinase (JAK)–signal transducers and activators of transcription pathway, a recently discovered pathway, has been shown to treat patients with atopic dermatitis. All four…
Janus Kinase Inhibitors in Dermatology: Part 2 - Applications in Psoriasis, Atopic Dermatitis, and Other Dermatoses.
Janus Kinase Inhibitors in Dermatology: Part 2: Applications in Psoriasis, Atopic Dermatitis, and Other Dermatoses.
Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
  • T. Bieber
  • Biology, Medicine
    Nature reviews. Drug discovery
  • 2021
TLDR
This Review assesses the various strategies and novel agents currently being investigated for AD and highlights the potential for a precision medicine approach to enable prevention and more effective long-term control of this complex disease.
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